Doctor's Best, PepZinGI, Zinc-L-Carnosine Complex, 120 Vegan Capsules, Lab Tested, Minerals, Gluten Free, SOYA Free, Vegetarian

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Authority to prescribe an Authority medicine is granted for specific indications and/or for certain patient circumstances. Authority may be obtained by telephone to Medicare Australia (known as "phone approval") or in writing from an authorised delegate of the Minister for Health. Over time, the gut lining can become weak, leading to increased intestinal permeability, for a variety of reasons, including one or more of the following insults (often a combination and typically persistent presence): Suzuki, A.; Kobayashi, R.; Okayasu, S.; Kuze, B.; Aoki, M.; Mizuta, K.; Itoh, Y. Pharmacotherapy for adverse events reduces the length of hospital stay in patients admitted to otolaryngology ward: A single arm intervention study. PLoS ONE 2014, 9, e115879. [ Google Scholar] [ CrossRef][ Green Version]

PepZin GI® has been described as effective, yet gentle, natural support to help maintain healthy gastric function and integrity. Have you been struggling for a while and feel like you’ve “tried everything” with little to no results to show? Hayakawa, A.; Inoue, M.; Kunizaki, M. Clinical evaluation of Z-103 on gastric ulcer. Yakuri Chiryo 1992, 20, 255–264. [ Google Scholar] Takaoka, T.; Sarukura, N.; Ueda, C.; Kitamura, Y.; Kalubi, B.; Toda, N.; Abe, K.; Yamamoto, S.; Takeda, N. Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment. Auris Nasus Larynx 2010, 37, 190–194. [ Google Scholar] [ CrossRef] Ko, J.K.; Leung, C.C. Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. J. Gastroenterol. Hepatol. 2010, 25, 1861–1869. [ Google Scholar] [ CrossRef] [ PubMed]Suzuki, Y.; Kasanuki, J.; Yoshida, H. Clinical evaluation of Z-103 on gastric ulcer Results of Phase II general clinical trial. Jpn. Pharm. Ther 1992, 20. [ Google Scholar] It has been reported that ZnC stimulated several aspects of gut mucosal integrity. In vitro studies using pro-migratory (wounded bilayer) and proliferation ([(3)H]-thymidine incorporation) assays of human colonic (HT29), rat intestinal epithelial (RIE), and canine kidney epithelial cells showed that ZnC stimulated cell migration and proliferation and reduced the amount of gastric and small intestinal injury in rats and mice. In vivo studies used a rat model of gastric damage (indomethacin/restraint) and a mouse model of small-intestinal (indomethacin) damage. Oral ZnC decreased gastric (75% reduction at 5 mg/mL) and small-intestinal injury (50% reduction in villus shortening at 40 mg/mL; both p< 0.01). In a cross over study of 10 healthy human subjects comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of indomethacin treatment (50 mg three times a day) with ZnC (37.5 mg twice daily) or placebo, it prevented the rise in gut permeability caused by indomethacin [ 7]. Shimada, T.; Watanabe, N.; Ohtsuka, Y.; Endoh, M.; Kojima, K.; Hiraishi, H.; Terano, A. Polaprezinc Down-Regulates Proinflammatory Cytokine-Induced Nuclear Factor-κB Activiation and Interleukin-8 Expression in Gastric Epithelial Cells. J. Pharmacol. Exp. Ther. 1999, 291, 345–352. [ Google Scholar] [ PubMed] Providing support for periodic GI discomfort, including occasional heartburn, tenderness, diarrhea and constipation Footnote †

Posthauer, M.E.; Banks, M.; Dorner, B.; Schols, J.M. The role of nutrition for pressure ulcer management: National pressure ulcer advisory panel, European pressure ulcer advisory panel, and pan pacific pressure injury alliance white paper. Adv. Ski. Wound Care 2015, 28, 175–188. [ Google Scholar] [ CrossRef][ Green Version]The selective permeability of the gut lining is regulated by specific structures. These structures are called “tight junctions.” Over time, these can become “loose,” resulting in increased intestinal permeability (aka leaky gut).