Canesflor Vaginal Probiotics | Helps Prevent Recurrence of Vaginal Infections such as Thrush | Clinically Proven - 10 Count (Pack of 1)

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Hans, V. & Rita, V. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev. Anti Infect. Ther. 7, 1109–1124 (2009).

Cs, B. & Rm, B. Making inroads into improving treatment of bacterial vaginosis—striving for long-term cure. BMC Infect. Dis. 15, 292 (2015). However, the main issue with using antibiotic treatment for BV is the high rate of recurrence within months of treatment 23. Relapse may occur when vaginosis-related bacteria re-colonize and take over the vaginal microbiome. Furthermore, vaginosis-related bacteria that recur after antibiotic treatment, such as Gardnerella vaginalis and Atopobium vaginae, may have higher resistance and become less sensitive to another round of antibiotic treatment 29, 30, 35. Also, orally administered metronidazole and clindamycin disturb the healthy gut microbiome 36, 37, whereas even local usage of antibiotics is a risk factor for vulvovaginal candidiasis 38, 39.Despite the growing clinical evidence, the efficacy of probiotic treatment on BV remains controversial [ 16, 17, 18]. Up to now, three meta-analyses have been reported [ 19, 20, 21], but none of them has explored the sources of interpretable heterogeneity and its influence on the results. One of them was published in 2009 in the Cochrane Library with only four studies. Another meta-analysis by Huang and colleagues exhibited a considerable heterogeneity ( I 2 = 87%) of the effect with no further explanations. The latest one, by Tan et al., only focused on the impact of probiotics as a supplementary therapy with metronidazole and attributed the heterogeneity ( I 2 = 83%) to one single study (the I 2 was reduced to 16% after omission of this single study) without further explanations. Thus, a widely accepted consensus has not been formulated yet. vesicoureteral reflux, L. acidophilus treatment daily was as effective as trimethoprim/sulfamethoxazole in reducing O’Hanlon, D. E., Moench, T. R. & Cone, R. A. In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide. BMC Infect. Dis. 11, 200 (2011). estrogen and progesterone HRT, only 1 to 3 species of bacteria, mainly Lactobacillus, were detected in the vaginal This is bad: they really sting! Insert as efficiciently as you can to avoid the stinging on the outside. Also, they are really messy! Insert at night and use a sanitary pad.

DeLong, K., Zulfiqar, F., Hoffmann, D. E., Tarzian, A. J. & Ensign, L. M. Vaginal microbiota transplantation: the next frontier. J. Law Med. Ethics 47, 555–567 (2019). vaginal douche containing > 1.0 × 10 8 colony-forming units/mL of L. acidophilus ( n = 32), or no treatment Lactobacillus crispatus LbV 88, Lactobacillus gasseri LbV 150N, Lactobacillus jensenii LbV 116 and Lactobacillus rhamnosus LbV96 Sexual Health and Wellness Institute. Clinical Trial to Survey Results of Flourish Vaginal Care System for Recurrent Bacterial Vaginosis. https://clinicaltrials.gov/ct2/show/NCT03734523 (2021). Stoyancheva, G., Marzotto, M., Dellaglio, F. & Torriani, S. Bacteriocin production and gene sequencing analysis from vaginal lactobacillus strains. Arch. Microbiol. 196, 645–653 (2014).Larsson, P.-G., Stray-Pedersen, B., Ryttig, K. R. & Larsen, S. Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study. BMC Women’s Health 8, 3 (2008).

With sequencing information obtained by the human microbiome project and many other vaginal microbiome investigations, we have learned that a large proportion of women without gynecological symptoms have a vaginal microbiome dominated by either L. crispatus or L. iners 2, 3, 4. While an L. crispatus-dominated vaginal microbiome is related to a healthy vaginal condition, L. iners-dominated and specially non- Lactobacillus-dominated vaginal microbiomes are linked to a higher risk for infections, such as human papillomavirus and Chlamydia trachomatis 1, 2. In contrast, probiotic therapy alone showed a better benefit in efficacy for BV treatment over the placebo. Since the products (H 2O 2 and lactic acid) produced by the lactobacilli have been found to inhibit the growth of BV-associated bacteria [ 52], we surmised the extraneous lactobacilli might gradually colonize the vaginal flora through competing. TSA analysis further indicated its promising clinical application. Given all that, the first-line therapy of antibiotics seemed unnecessary by contrast with the effective probiotics-only therapy. growth of pathogens, including some associated with BV, such as G. vaginalis [ 86]. Only relatively recently has a study shown in animals that bacteriocin Since some quite strict eligibility criteria were set, we would relax them one by one in sensitivity analyses, with other factors being equal. New RCTs with the following characteristics were included: studies with abstracts only, with food or dietary supplements as interventions, with a high risk of bias, less than 20 participants, or with non-blind outcome assessment. We re-evaluated the overall effects to see there was any change. We also investigated attrition, such as dropouts, loss to follow-up and withdrawals. No outcomes of efficacy or safety were imputed according to the principle of analysis. susceptible to UTI, it was discovered that immunological defects in peripheral blood coexisted with a persistentlyMastromarino, P. et al. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin. Microbiol Infect. 15, 67–74 (2009). Speak to your healthcare practitioner for more information about supplementation. Make sure to always read the label and use only as directed. If symptoms persist, see your healthcare practitioner. United States Food and Drug Administration. Fecal microbiota for transplantation: safety alert—risk of serious adverse events likely due to transmission of pathogenic organisms. FDA. https://www.fda.gov/safety/medical-product-safety-information/fecal-microbiota-transplantation-safety-alert-risk-serious-adverse-events-likely-due-transmission (2020).

coverage of epithelial cells noted in healthy women [ 8]. In addition, lactobacilli have been shown to bind (coaggregate) Parent, D. et al. Therapy of bacterial vaginosis using exogenously-applied Lactobacilli acidophili and a low dose of estriol: a placebo-controlled multicentric clinical trial. Arzneimittelforschung 46, 68–73 (1996).This unsustainable therapeutic impact on BV may limit our understanding of its pathogenesis. For a long time, BV has been regarded as an infectious disease caused by anaerobes, such as Gardnerella vaginalis. However, with the advent of culture-independent molecular approaches based on the sequencing of 16S rRNA genes, our understanding of the vaginal microbiome (VMB) has been dramatically improved. Several studies indicated that VMB might play a key role in the development of BV [ 9]. The occurrence of BV may be associated with the composition and metabolism of certain types of VMB, and probiotics, especially lactobacilli-based, are effective in preventing urogenital diseases [ 10].