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Yano, S. et al. Current states and future views in photodynamic therapy. J. Photochem. Photobiol. C: Photochem. Rev. 12, 46–67 (2011). Kamat, P. V. et al. Excited-state properties and photosensitization behaviour of bis(2,4-dihydroxyphenyl)squaraine. J. Chem. Soc., Faraday Trans. 89, 2397–2402 (1993). Luke, G. P., Yeager, D. & Emelianov, S. Y. Biomedical applications of photoacoustic imaging with exogenous contrast agents. Ann. Biomed. Eng. 40, 422–437 (2012). Wang, L. V. & Hu, S. Photoacoustic tomography: In vivo imaging from organelles to organs. Science 335, 1458–1462 (2012). To finalize the translation from research to routine clinical use, iThera Medical signed the €13 million funding round. The proceeds from this funding round will be used to develop a next-generation MSOT device optimized for routine clinical use, to secure regulatory approval for deployment in Europe and the United States (CE- and FDA-approval), and to significantly expand clinical evidence in priority clinical indications.

iThera Medical has developed Multispectral Optoacoustic Tomography (MSOT), a breakthrough imaging technology that utilizes the photoacoustic effect – describing the conversion of light energy into sound waves – to visualize optical contrast, at high resolution in deep tissue. In conclusion, this preliminary study suggests that MSOT-based assessment of hemoglobin levels in the intestinal wall has the potential to be used to distinguish active disease from remission in patients with Crohn’s disease without the need for more invasive procedures; further study is needed.Burton, N. C. et al. Multispectral optoacoustic tomography (MSOT) of the brain and glioblastoma characterization. NeuroImage 65, 522–528 (2013). All animal experimental procedures were performed in accordance with the protocol #120774 approved by the Institutional Animal Care and Use Committee (IACUC). Xenograft mice models were established by injecting subcutaneously into the right flank of mouse, 0.2 mL of cell suspension containing 5–6 × 10 6 MCF-7, a human metastatic breast cancer cell line or OSCC, a human oral squamous carcinoma cell line and matrigel (BD biosciences) in 1:1 volume ratio. When the tumor volume reached a palpable size, the mouse was used for in vivo PA imaging. In vivo longitudinal monitoring of probe biodistribution in mouse xenograft model NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. Stein, E. W., Maslov, K. & Wang, L. V. Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy. J. Biomed. Opt. 14, 020502 (2009). The funding will drive the company’s continued innovation and commercialization of its novel medical imaging technology, with a specific goal to translate the technology into a routine clinical environment and offer clinicians worldwide a powerful new diagnostic tool.

Lovell, J. F., Liu, T. W. B., Chen, J. & Zheng, G. Activatable photosensitizers for imaging and therapy. Chem. Rev. 110, 2839–2857 (2010). Inés, Y. E. et al. Biodistribution of phototherapeutic properties of zinc (II) 2, 9, 16, 23-tetrakis (methooxy) phthalocyanine in vivo. Photodiagn. Photodyn. Therapy. 6, 62–70 (2009). Concise summaries and expert physician commentary that busy clinicians need to enhance patient care.iTHERAU Large Infrared Light Therapy Belt is an innovative product that uses advanced technology to distribute 360 LED beads on a 31.49*11.81 inch extra-large treatment pad, each bead inside has three chips, emitting 660nm red light and 850nm infrared light respectively. Optoacoustic imaging offers a multitude of applications.Medical scanning technology company iThera Medical has announced successful closure of €13 million investment round, led by Trumpf Venture with participation by the EIC Fund as co-investor in addition to existing investors Mey Capital Matrix, Wachstumsfonds Bayern, BayBG, Fluxunit, Falk Strascheg Holding, and Occident. Rouleau, L. et al. VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice. Contrast Media Mol. Imag. 8, 27–39 (2013).

Christian Wiest, CEO and co-founder of iThera Medical, said, “This funding round is the next major step to translate our MSOT technology from a tool in research to a diagnostic asset in a clinical setting, where we believe it will be a game-changer for millions of patients worldwide.” Herzog, E. et al. Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography. Radiology. 263, 461–468 (2012). The authorized source of trusted medical research and education for the Chinese-language medical community. Greish, K. Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. Cancer Nanotech. Methods Mol. Biol. 624, 25–37 (2010).

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Kircher, M. F. et al. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nat. Med. 18, 829–834 (2012). Buehler, A. et al. High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography. EJNIMMI Research. 2 (2012). In clinical practice, a wide range of diagnostic procedures are essential for clinicians to diagnose disease and monitor treatment response. However, many fields have an unmet need for accurate, objective, and quantitative approaches.