BEE VENOM CREAM - 30ml FAST RELIEF MUSCLE JOINT PAIN VERY EFFECTIVE

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Kim H, Keum DJ, Kwak JW, Chung H-S, Bae H. Bee venom phospholipase a2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice. PLoS ONE. (2014) 9:e114726. doi: 10.1371/journal.pone.0114726 Muller U, Thurnheer U, Patrizzii R, Spies J, Hoigne R. Immunotherapy in bee sting hypersensitivity: bee venom versus whole body extract. Allergy. (1979) 34:369–78. doi: 10.1111/j.1398-9995.1979.tb02006.x Low doses of BV trigger a range of anti-inflammatory responses that have been explored in diabetes, rheumatoid arthritis (RA), heart diseases, obesity, asthma, skin diseases, and central nervous system-associated diseases (Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis) ( 63, 64). BV suppresses inflammatory cytokines, including interleukin-6 (IL-6), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). A decrease in the signaling pathways responsible for the activation of inflammatory cytokines, nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinases (ERK1/2) and protein kinase Akt, and Porphyromonas gingivalis lipopolysaccharide (PgLPS)-treated human keratinocytes are associated with melittin treatment( 65) ( Figure 2). Host Responses to Bee Venom

The warm and tingling sensation that this anti-aging mask gives the skin is the bee venom in its formula working to stimulate and increase the body's wrinkle-smoothing collagen and elastin to plump and tighten the skin. Leave it on for 10 minutes one to two times a week to visibly minimize visible signs of again like wrinkles and fine lines.Cho SY, Shim SR, Rhee HY, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. View abstract. Subbalakshmi C, Nagaraj R, Sitaram N. Biological activities of C-terminal 15-residue synthetic fragment of melittin: design of an analog with improved antibacterial activity. FEBS Lett 1999;448:62-6. View abstract.

A leading adjuvant of SARS-CoV-2 therapies currently being promoted is aluminum hydroxide due to its slow release and increased interaction with antigen presenting cells ( 115). Bee venom offers a candidate for control SARS-CoV-2 infections and could offer advantages against COVID-19. PLA 2 has been associated with a level of success against SARS-CoV-2 infections ( 116, 117). Conjugation of BV peptides could offer a new approach in the development of the BV vaccine. Potential Relationship Between Bee Venom Proteins and COVID-19 Proteins Mason RJ. Pathogenesis of COVID-19 from a cell biology perspective. Eur Respir J. (2020) 55:9–11. doi: 10.1183/13993003.00607-2020 Multiple skincare companies have started adding bee venom to products like serums and moisturizers. This ingredient may promote skin health in several ways, including by reducing inflammation, providing antibacterial effects, and reducing wrinkles. Cho SY, Lee YE, Doo KH, et al. Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson's disease. J Altern Complement Med 2018;24(1):25-32. View abstract. Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. (2020) 395:1569–78. doi: 10.1016/S0140-6736(20)31022-9

Biological Variability of Bee Venom Composition Among Bee Variants for Biotoxin Administration in Complementary Medicine

Li JT, Yunginger JW. Management of insect sting hypersensitivity. Mayo Clin Proc 1992;67:188-94. View abstract. Baek YH, Huh JE, Lee JD, Choi DY, Park DS. Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: mediation by α2-Adrenoceptors. Brain Res. (2006) 1073–1074:305–10. doi: 10.1016/j.brainres.2005.12.086 An extreme performance eye cream to smooth out under eye wrinkles, brighten dark circles and firm the skin with bee venom, stem cell technology and melittin peptide.