Anatomic Line Cryogel Muscle & Joint Pain Relief Gel for Back, Neck & Shoulders Ache 100ml

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This is a property which can easily be applied and manipulated through careful polymer selection. For example, altering the ratio of hydrophobic and hydrophilic polymers in the final cryogel structure can allow for fine tuning of the responsive behaviour [33,34]. Abdullah, T.; Colombani, T.; Alade, T.; Bencherif, S.A.; Memic, A. Injectable lignin-co-gelatin cryogels with antioxidant and antibacterial properties for biomedical applications. Biomacromolecules 2021, 22, 4110–4121. [ Google Scholar] [ CrossRef] The antifungal agent voriconazole was incorporated into a physically crosslinked cryogel comprising PVA and chitosan grafted with NIPAAm (CS- g-PNIPAM) for mucosal applications [98]. Cell culture assays confirmed that the cryogels were non-toxic and the release profiles of voriconazole from a CS- g-PNIPAM/PVA 75/25 gel showed release of up to 80% of the encapsulated drug over a period of 8 hours. Sustained release of diclofenac over two weeks was studied using natural biopolymer kefiran cryogels [99]. Kefiran is a biocompatible water-soluble branched polysaccharide, isolated from kefir grains. Scaffolds were prepared by cryogelation of a 2% w/v aqueous solution of the kefiran, without the need for any crosslinking agents. Release of diclofenac, a non-steroidal anti-inflammatory drug, was low with 15% of the drug released after 2 weeks. However, this could result in a sustained release over longer time periods which would require further investigation. Doxorubicin release from heparin-containing cryogel microcarriers was investigated by Newland et al. [100]. Highly sulphated heparin was used to exploit electrostatic interactions between anionic sulphate groups and the primary amine group present in doxorubicin which confers a positive charge under physiological conditions. This interaction was confirmed by in silico modelling. While the carriers did not show any cytotoxicity, cell viability was reduced in the presence of the doxorubicin-loaded cryogels, suggesting delivery of the drug was successful. These cryogels were also injected into mice, adjacent to an orthotopic breast cancer tumour, impeding tumour growth and metastasis. Li, G.; Sun, S. Silk fibroin-based biomaterials for tissue engineering applications. Molecules 2022, 27, 2757. [ Google Scholar] [ CrossRef] Kasoju, N.; Bora, U. Silk fibroin in tissue engineering. Adv. Healthc. Mater. 2012, 1, 393–412. [ Google Scholar] [ CrossRef]

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